Although the origins of the first Franciscan oratory are still lost in the mists of time, the construction of the new Basilica of Santa Croce is well documented and was officially started on May 3rd 1294, when the architect, Arnolfo di Cambio, laid the first stone of what was to become a masterpiece of Gothic art.

His design was based on spatial grandiosity, with the structural elements carried out with rational clarity and sobriety. It is built on the plan of an Egyptian cross (in the shape of a T), with the interior divided into three naves (114,45 metres), a chancel and a transept full of chapels whose patronage was reserved for the most illustrious families in this quarter of the city: the Bardi and Peruzzi families were the foremost, but there were also the Tosinghi, Pulci, Rinuccini and Alberti families.

The basilica also contains numerous examples of typically Renaissance sculpture. The most famous of these is the Crucifix by Donatello (1425, Bardi Chapel in the left transept) and his aristocratic Annunciation in grey stone with gilded highlights.

In the Primo Chiostro, the main cloister, is the Cappella dei Pazzi, built as the chapter house by Filippo Brunelleschi between 1442 and 1446 and finally completed in the 1470s. The Museo dell'Opera di Santa Croce is housed mainly in the refectory, also off the cloister. A monument to Florence Nightingale stands in the cloister, in the city in which she was born and after which she was named. Brunelleschi also built the inner cloister, completed in 1453.

Today the former dormitory of the Franciscan Friars houses the Scuola del Cuoio (Leather School)[1]. Visitors can watch as artisans craft purses, wallets, and other leather goods which are sold in the adjacent shop.